You are correct. A biopsy showed squamoproliferative change with evidence of dermal inflammation, suggestive of nodular prurigo, an idiopathic condition characterized by itchy, firm lumps. “Saddle sores” are well recognized in the cycling fraternity but clinicians may not be familiar with this condition. Once established, treatment can be challenging. The use of specialized shorts, anti-chafing cream (often referred to as chamois cream), and excellent hygiene are recommended.