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<sup>18</sup> For pts requiring long-term PPI tx, it should be administered in the lowest effective dose, incl. on-demand or intermittent tx [C/L]. If pts experience heartburn relief w/ H2RA: H2RA can be a maintenance option in pts w/o erosive dz [C/M]. <br><br>
GERD tx other than acid suppression (eg, prokinetic tx, baclofen) should NOT be used w/o dx eval [C/M]; there is no role for sucralfate in the nonpregnant pt [C/M]. Routine tx of <i>H pylori</i> infxn NOT recommended in GERD tx [S/L].
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<sup>19</sup> Traditional delayed-release PPIs should be administered 30-60 min ac for max pH control [S/M]; newer PPIs may offer dosing flexibility relative to mealtime [C/M].
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<sup>20</sup> PPI switching is common in practice; there are limited data to support this; no data to support switching PPIs ≥1x in partial/nonresponders. Meta-analyses fail to show significant efficacy difference for sx relief between PPIs.
GERD tx other than acid suppression (eg, prokinetic tx, baclofen) should NOT be used w/o dx eval [C/M]; there is no role for sucralfate in the nonpregnant pt [C/M]. Routine tx of <i>H pylori</i> infxn NOT recommended in GERD tx [S/L].
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<sup>19</sup> Traditional delayed-release PPIs should be administered 30-60 min ac for max pH control [S/M]; newer PPIs may offer dosing flexibility relative to mealtime [C/M].
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<sup>20</sup> PPI switching is common in practice; there are limited data to support this; no data to support switching PPIs ≥1x in partial/nonresponders. Meta-analyses fail to show significant efficacy difference for sx relief between PPIs.
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