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<sup>5</sup> Drug order does not denote preference. Customize per pt and dz factors (eg, efficacy, cost, potential side effects, weight, comorbidities, hypoglyc risk, pt preference) [E]. Individualize targets; in many nonpregnant adults: A1C <7%, preprandial PG 80-130 mg/dL, postprandial PG (1-2h after beginning of meal) <180 mg/dL.<br><br>
<sup>6</sup> Metformin characteristics: ↓ HbA1C efficacy: ++; hypoglyc risk: low; wt: neutral/↓; ADRs: GI/lactic acidosis; cost: $.
<sup>6</sup> Metformin characteristics: ↓ HbA1C efficacy: ++; hypoglyc risk: low; wt: neutral/↓; ADRs: GI/lactic acidosis; cost: $.
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Add 2nd drug<sup>5</sup> to metformin<sup>6</sup> after 3-mo max-tolerated noninsulin tx [A]