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<sup>23</sup> Contraindicated in smokers >35 yo, HTN, hx DVT or PE, thromboembolic disorder, cerebrovascular dz, ischemic heart dz, migraine w/ aura, current/past breast CA, severe liver dz, DM w/ vascular involvement, valvular heart dz w/ complications, major surgery w/ prolonged immobilization. <br><br><sup>24</sup> Contraindicated if active/hx DVT or PE, active or recent thromboembolic dz, current/past breast CA, impaired liver function, or liver dz. <br><br>
<sup>25</sup> Tranexamic acid has not been studied in acute AUB. Contraindicated if impaired color vision and current thrombotic or thromboembolic dz. Use w/ caution in pts w/ hx of thrombosis, and caution w/ concomitant use of OCPs. <br><br>
<sup>26</sup> Suspect possible bleeding disorder if: menorrhagia since menarche + hx of either postpartum hemorrhage, surgery-related bleeding, or bleeding w/ dental work + ≥2 of the following: monthly ecchymosis, monthly epistaxis, frequent gum bleeding, or FHx of bleeding.
<sup>25</sup> Tranexamic acid has not been studied in acute AUB. Contraindicated if impaired color vision and current thrombotic or thromboembolic dz. Use w/ caution in pts w/ hx of thrombosis, and caution w/ concomitant use of OCPs. <br><br>
<sup>26</sup> Suspect possible bleeding disorder if: menorrhagia since menarche + hx of either postpartum hemorrhage, surgery-related bleeding, or bleeding w/ dental work + ≥2 of the following: monthly ecchymosis, monthly epistaxis, frequent gum bleeding, or FHx of bleeding.
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