PrEP may be indicated if: neg HIV test, no s/sx of acute HIV infxn [IA], normal renal fxn,<sup>7</sup> documented HBV/vaccine status.

By makin, 21 October, 2014
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<sup>7</sup> Do not start PrEP if eCrCl <60 mL/min. Recheck renal status at 3 mo, then q6mo thereafter. D/C PrEP If renal failure detected [IIIA]. <br><br>
<sup>8</sup> Use of antiretrovirals other than TDF/FTC (or TDF) is not recommended [IIIA]. Prescription of oral PrEP for coitally timed or other noncontinuous daily use is not recommended [IIIA].
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<sup>9</sup> TDF/FTC alone is inadequate tx for established HIV infxn, & its use may lead to drug resistance [IA].
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<sup>10</sup> If pregnancy desired, follow guidance for serodiscordant couples at time of conception/preg.
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