For pts meeting dx criteria¹³ and severe enough to require hospitalization:^14,15

¹³ Dx: URI w/ 1) Persistent nonimproving s/sx ≥10 days; or 2) Severe sx: Temp ≥39°C and purulent nasal d/c or face pain for 3-4 days at onset; or 3) Worsening s/sx including new fever/HA/nasal d/c increase following typical 5-6 days URI that initially improved (double-sickening). [S/L-M]<br><br>¹⁴ Consult specialist for pts who are seriously ill, immunocompromised, or who do not respond to tx.
<br><br>¹⁵ Not recommended: oral cephalosporins as empiric mono-tx [W/M], macrolides, TMP/SMX. [S/M]