Step 4 single inhaler maintenance reliever tx SMART med dose ICS formoterol daily prn sx max 12 puffs day 54 mcg formoterol alternatives w prn SABA med dose ICS either LABA LAMA LTRA or theophylline or zileuton3

<b> Step 4:</b> single-inhaler maintenance & reliever tx (SMART): med-dose ICS-formoterol daily & prn sx (max 12 puffs/day = 54 mcg formoterol); alternatives (w/ prn SABA): med-dose ICS + either LABA, LAMA, LTRA or theophylline, or zileuton³