If typical heartburn and or regurgitation w o alarm sx or extraesophageal sx presumptive GERD dx can be established 2 4 tx empirically w qd PPI taken 30 60min before a meal 4 6 use lowest effective dose 4 6 d c PPI at end of 8wk in pts who respond 4 H2 bl

If typical <strong>heartburn and/or regurgitation w/o alarm sx</strong> or extraesophageal sx, presumptive GERD dx can be established;^2,4 tx empirically w/ qd PPI, taken 30-60min before a meal; ^4,6 use lowest effective dose,^4,6 d/c PPI at end of 8wk in pts who respond;⁴ H2 blockers less effective, but better than placebo¹