By vgreene, 20 May, 2015
(BMJ)—A previously healthy 6-mo-old girl had fever x 4 days and a deep, black eschar surrounded by ulceration on her R cheek that rapidly evolved despite tx w/ calendula and gentamycin homeopathic ointment. Labs: WBC 10.6, elevated CRP. What is the dx?
Pyoderma gangrenosum
Cutaneous anthrax
Brown recluse spider bite
Ecthyma gangrenosum
Burn from nonaccidental trauma
You are correct. Ecthyma gangrenosum (EG) is a rare cutaneous infection often caused by Pseudomonas aeruginosa, although other bacteria, fungi, and viruses can be responsible. A skin swab grew Pseudomonas aeruginosa; blood cultures were negative. EG usually occurs in children with known immunocompromise, but sometimes it also occurs in healthy children, as indicative of sepsis or immunodeficiency. Serum immunoglobulin values checked after resolution of infection in this pt turned out normal. Fever ceased within 24 hrs after intravenous antibiotic therapy w/ piperacillin-tazobactam and tobramycin, and the lesion quickly improved, leaving a residual scar.