You are correct. Ticagrelor reduces platelet activation and aggregation, and significant bleeding may occur with use of this drug. Cyclosporine, a moderate CYP3A4 inhibitor and strong P-glycoprotein (P-gp) inhibitor, inhibits the metabolism and P-gp–mediated transport of ticagrelor, leading to increased systemic exposure and risk of adverse effects; therefore, coadministration with cyclosporine should be used with caution. Furthermore, ticagrelor, a weak CYP3A4 inhibitor and weak P-gp inhibitor, inhibits the metabolism and P-gp–mediated transport of cyclosporine, leading to increased systemic exposure.

No significant interactions are known or found for aspirin and mycophenolate, though GI perforation and bleeding have been reported with aspirin alone.

Though bleeding isn’t associated with cyclosporine and olmesartan, the combined use of cyclosporine and olmesartan may increase the additive risk of hyperkalemia and nephrotoxicity, warranting monitoring of potassium and renal function.

Though bleeding isn’t associated with artorvastatin and ticagrelor, ticagrelor (weak P-gp inhibitor) may increase atorvastatin levels via inhibition of P-gp–mediated transport of atorvastatin, leading to an increased risk of myopathy, rhabdomyolysis, and other adverse effects.

Source article: Zhang C, Shen L, Cui M, Liu X, Gu Z. Ticagrelor-induced life-threatening bleeding via the cyclosporine-mediated drug interaction: A case report. Medicine (Baltimore). 2017;96(37):e8065. doi: 10.1097/MD.0000000000008065.

More info is available in the free, full-text Medicine (Baltimore) article PDF at PubMed Central.

You are correct. Data on 947 adults with type 1 diabetes showed that 37% did not receive a diagnosis until after the age of 30, and delayed diagnoses were most common among men and diverse racial groups, according to findings published in the journal Annals of Internal Medicine.

Fang M, et al. (2023, September 26). Ann Intern Med. PubMed® abstract

You are correct. Levofloxacin is a fluoroquinolone antibiotic used to treat pneumonia, prostatitis, bacterial skin infections, and UTI, among other infections. It's also used to treat adults and children exposed to anthrax or plague.

As a reminder, you can use the Pill ID feature to identify a pill based on its imprint code or physical characteristics, including shape, color, and scoring. Find Pill ID in the epocrates app or on epocrates web.