Step up at least 1 tx step for not well controlled dz 1 1st review adherence inhaler technique environment control

By vgreene, 17 June, 2015
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<sup>1</sup> <b>Not well controlled</b> = sx/SABA use >2 days/wk (but not throughout day), sx 1-3 nights/wk, some limitations to NL activity, FEV1 60%-80%, ≥2 exac/yr requiring PO/IV steroids (inadequate data to correlate exac freq w/ control; but more frequent/more intense exacs indicate poorer asthma control). Most important determinant of dosing = clinician judgment of response to tx: sx, activity level, lung fxn. <br><br>
<sup>2</sup> Available SABAs (in alpha order):<br>
<b>• albuterol MDI</b> 90 mcg 2 puffs q4-6h prn<br>
<b>• albuterol NEB</b> 1.25-5 mg in 3 cc saline q4-8h prn<br>
<b>• levalbuterol MDI</b> 45 mcg 2 puffs q4-6h prn<br>
<b>• levalbuterol NEB</b> 0.31-0.63 mg q8h prn
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<sup>3</sup> <b>Oral steroids</b> (options listed in EPR-3 Quick Reference 2012, in alpha order): methylprednisolone, prednisolone, or prednisone: 0.25-2 mg/kg daily (single AM dose) or every other day as needed for control. Short-course burst to gain control: 1-2 mg/kg/day (max 60 mg/day) x3–10 days.
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Step up at least 1 tx step for not-well-controlled dz;<sup>1</sup> 1st review adherence, inhaler technique, environment control